Genetics + Genomics

Some of the most important tools in researchers’ toolkits are the model organisms they use to study biological questions. How do researchers decide which species, out of the millions that exist, to develop as models? Whitehead Institute researchers have had a hand in establishing and promoting the use of several model organisms over the years.

The new system streamlines the process of fermenting plant sugar to fuel by helping yeast survive industrial toxins.

Researchers in Whitehead Institute Director Ruth Lehmann’s lab have discovered that swarm cells, a previously enigmatic cell type, help primordial germ cells time their transformation during development so that the ovary can successfully assemble for egg production. 

A paper from the lab of Whitehead Institute Member Rudolf Jaenisch suggests that the genetic material of SARS-CoV-2 can integrate into the host cell genome and be expressed in some patient-derived tissues.

Melissa Pamula is a postdoc in Whitehead Institute Director Ruth Lehmann’s lab studying the cells that make and become eggs and sperm. We sat down with Melissa to learn more about her and her experiences in and out of the lab.

Researchers at Whitehead Institute propose a new model for how the stem cells in aquatic worms called planarians commit to a specific fate. Instead of a long, slow process that occurs over many generations, the researchers suggest that the transition from “blank” stem cells to specialized cells could happen in a single division.

New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged