Human colon cancer cells

Postdoc Jason Moffat silenced particular genes in human colon cancer cells and then fluorescently labeled several components of the cells to expose cell division problems. In the top four images, he labeled DNA blue, actin red (to outline the cell shape), and a structural protein that is detectably modified through mitosis green. He used a similar labeling scheme in the bottom two images, though he dropped the actin label and added one for a structural component of microtubules.