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whitehead home > research news > on topic > y chromosome

On Topic: Y Chromosome

Long thought to be the black sheep of the DNA world, the Y chromosome has made a comeback. For decades scientists have believed that the Y is headed for extinction, and that in another few million years this chromosome, which confers maleness, will no longer exist. This demise of manhood was based on the assumption that because the Y does not have a mate (all other chromosomes come in pairs), it can't fix its own genetic damage by swapping genes with a counterpart. Whitehead Director David Page has now turned that theory on its head. By sequencing the Y chromosome, Page has demonstrated that it possesses a system of self-repair unique to the genome, and that rumors of its demise have been greatly exaggerated-something that men of all species can take comfort in.



Video

David Page The Evolution of Sex: Rethinking the Rotting Y Chromosome
David Page, Director
Whitehead Institute
From the Director's Lecture Series for Non-Scientists
December 8, 2003

[view QuickTime video 220k 56k] Video length: 1:20:28

Whitehead News Stories

Human Y chromosome stays intact while chimp Y loses genes (2005)
The "Y" files (2003)
Rumors of male chromosome's  demise greatly exaggerated (2003)
Men are not in the driver's seat of human evolution (2000)
Tracing the evolution of sex chromosomes (1999)

Related Links

NPR: As Y chromosome shrinks, end of men pondered
Scientific American: Geographer of the Male Genome

HHMI: Searching the Y chromosome for a "house with green shutters"
HHMI News: David Page and the Y chromosome
Nature Web Focus: The Y chromosome

Last updated October 20, 2005.

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