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Recent research in embryonic stem cells


ARTICLES

Image: Adult cells converted to a more pluripotent stateique
Scientists create human embryonic stem cells with enhanced pluripotency
Whitehead Institute researchers have converted established human induced pluripotent stem (iPS) cells and human embryonic stem (ES) cells to a base state of greater pluripotency.

Image: Diagram of new stem cell technique
New technique produces genetically identical stem cells
Cells from mice created using genetically reprogrammed cells can be triggered via drug to enter an embryonic stem-cell-like state.


Image: Mouse neuron
Recipe for reprogramming
The science of induced pluripotent stem cells advances rapidly in mice.


MULTIMEDIA

Photo: Mouse from IPS cells

Stem cells breakthrough
NOVA Science NOW segment
 [link to NOVA]
 

Photo: Rudolf Jaenisch

Mature B cells reprogrammed to stem-cell-like state
Whitehead Member Rudolf Jaenisch April 2008
 [view video 220k]
  Video length: 03:56

Photo: Rudolf Jaenisch

Reprogram-
med cells reduce Parkinson's symptoms in rats

Whitehead Member Rudolf Jaenisch April 2008
 [view video 220k]
  Video length: 01:16

Photo: Richard Young

Mapping a new frontier: human regulatory circuitry
Whitehead Member Richard Young January 2008
 [view video 220k]
  Video length: 50:32

whitehead home > research news > on topic > stem cells > basics
Whitehead Research on Stem Cell and Regenerative Biology
Basics
Whitehead Researchers
Embryonic Stem Cells
Adult Stem Cells
Cancer Stem Cells

Basics

Stem cells have two properties that distinguish them from other cells. First, stem cells regenerate themselves. When a stem cell divides, it creates two daughter cells, the first of which is an exact replica of itself. Second, embryonic stem cells are “undifferentiated”—that is, they are not committed to becoming any particular type of cell, such as a neuron or skin cell.

These special cells hold unusual promise to improve human health. Here are resources with background information on stem cells and selected stories on the fast-moving research to understand them.

Overview:

Stem cell research 101
Our primer defining different types of stem cells and exploring current trends in stem cell research

Embryonic stem cells:

Recipe for reprogramming (2008)
Creating neurons from mouse and rat IPS cells, and generating IPS cells from fully developed B cells

Break no eggs (2007)
Introducing the recently created embryonic-stem-cell-like “induced pluripotent stem” (IPS) cells

Adult stem cells:

There will be blood stem cells (2008)
Human blood stem cells are multiplied 20-fold in culture, offering promise for bone-marrow transplants

Promises and realities in embryonic stem cell research (2007)
Whitehead Member Rudolf Jaenisch explains that it's still early days for the science, despite all the controversies.

Q&As on adult stem cells (2006)
Whitehead Fellow Fernando Camargo explaining where adult stem cells are found, how their therapeutic potential differs from that of embryonic stem cells and how adult stem cells are currently used to cure diseases

Power in the blood (2006)
Progress in building up the adult stem cells that build your blood

 

Recent research in adult stem cells


ARTICLES

Figuring out the heads or tails decision in regeneration
A molecular connection between wounding and the onset of the regeneration of an entire head or tail in planaria has been identified.

There will be blood stem cells
Human cells are multiplied 20-fold in culture, offering promise for bone-marrow transplants.

Image: Human breast cells that underwent an embryonic program have a trait of stem cells.
A simple twist of cell fate
Tapping an embryonic program, adult cells gain properties of stem cells.

 

MULTIMEDIA

Photo: Robert WeinbergEmbryonic pathway delivers stem cell traits
Whitehead Member Robert Weinberg April 2008
 [view video 220k]
  Video length: 03:41

Illustration: PlanariaRegenera- tion in planaria
From the Whitehead exhibit at the MIT Museum October 2007
 [interactive presentation]

Photo: Peter ReddienHow evolution reused its inventions
Whitehead Member Peter Reddien October 2007
[view video 220k]
  Video length: 02:16

Photo: Harvey LodishGrowing blood-form- ing stem cells in culture— implications for human medicine
Whitehead Member Harvey Lodish February 2007
[view video 220k]
  Video length: 51:02

 

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