Calculating gene and protein connections in a Parkinson’s model
Cells respond to stimuli with changes in many processes, including gene expression and cellular communications that coordinate a cell’s activities (cell signaling pathways). The figure shows a general signaling pathway.
Genetic screen data (the results from altering one gene in a cell's genome and seeing what observable traits appear in the cell) and information on gene expression identify only some of these molecular components and often do not identify the same genes. (Proteins identified in genetic screens are colored blue, and the products of expressed genes are purple.) ResponseNet identifies cellular communication pathways that link these two types of data and predicts proteins that are part of these pathways even if they are not identified in either screen (colored red).
