The Hsp90-antifungal combo, please: Compromising fungi in the immunocompromised

The researchers found that when antifungals or Hsp90 inhibitors are used individually, they are ineffective; however, when paired they form a deadly duo. Not only did this work in a test tube, but it also worked to cure a lethal infection in an invertebrate model of fungal disease. On the left, are greater wax moth (Galleria mellonella) larvae that are light colored and healthy while on the right are those that were killed by a deadly fungus. Amazingly, the drug combination can rescue 100% of the larvae.

Images: Copyright 2009 National Academy of Sciences, U.S.A.