Image:
Copyright 2009 National Academy of Sciences, U.S.A.
The top image shows a sample from a normal prostate, with organized cells lining the O-shaped ductules.
Mice without the PTEN gene had developed cancer, which is characterized by enlarged glands and disorganized cells clogging the ductules (middle image).
When mTORC2 activity is blocked in mice lacking the PTEN gene, the prostate ductules resemble the appearance of normal prostate samples, with organized cells along the ductules (bottom image).
