Scientists Identify Dual Function for "Eyes absent"

CAMBRIDGE, Mass. (Nov. 19, 2003) — Scientists know that proteins called transcription factors that regulate gene expression play a key role in cellular function. But what if that’s only part of the story? What if these regulators lead a double life no one knew before?

In a study published in this week’s journal Nature, scientists at Whitehead Institute have discovered that a transcription factor known as “Eyes absent,” which helps to regulate eye development, also functions as a enzyme that has the ability to modify itself and other proteins. This is the first time scientists have identified this dual function for a transcription factor, a finding that could reveal new information about cellular regulation.

Whitehead Institute for Biomedical Research is a nonprofit, independent research and educational institution. Wholly independent in its governance, finances and research programs, Whitehead shares a close affiliation with the Massachusetts Institute of Technology through its faculty, who hold joint MIT appointments.